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KMID : 0648320080140010023
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Journal of The Korean Society of Hypertension
2008 Volume.14 No. 1 p.23 ~ p.30
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Serum levels of advanced glycation end products and soluble receptor for advanced glycation end products for the prediction of coronary artery disease in non-diabetic subjects
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Rhee Moo-Yong
Na Sang-Hoon
Kim Yong-Seok
Bae Jun-Ho
Nah Deuk-Young
Kim Young-Kwon
Lee Myoung-Mook
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Abstract
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Purpose : Advanced glycation end products (AGE) may play a role in the development of atherosclerosis through the activation of the receptor for AGE (RAGE). We investigated the association of serum levels of AGE and soluble RAGE (sRAGE) with the presence and severity of coronary artery disease (CAD).
Methods : Serum levels of AGE and sRAGE were measured with ELISA in samples obtained from patients underwent coronary angiography. Patients with diabetes, heart failure, myocardial infarction, and who had received coronary intervention previously, were not included. Patients with diameter stenosis 50% by quantitative coronary analysis (n=38; mean age±SD, 63±10 years; 23 men) and normal coronary arteries (n=37; 58±9 years; 23 men) were studied.
Results : Serum levels of AGE were significantly higher in patients with CAD than in patients without CAD (mean±SD, 192±48 vs. 118±49 U; p=0.025). Serum levels of sRAGE were significantly lower in patient with CAD than in patients without CAD (1016±467 vs 1350±749 pg/mL; p=0.048). Serum levels of AGE was positively correlated with Gensini score (r=0.239, p=0.020) and sRAGE was negatively correlated (r=-0.260, p=0.013). Multiple regression analysis adjusted with age, gender, body mass index, systolic blood pressure, total cholesterol, smoking, showed significant correlation between serum AGE level and Gensini score (beta=0.278, p=0.025). However, serum sRAGE was not correlated to Gensini score (beta=-0.260, p=0.059). Multivariate adjusted odds ratio (OR) of AGE for the presence of CAD was 1.010 (95% CI, 1.002-1.018, p=0.020). For sRAGE, OR was 0.260 (95% CI, 0.070-0.964, p=0.044).
Conclusions : The present study shows independent association of high levels of serum AGE and low levels of serum sRAGE with the presence of CAD. This result suggests that AGE and sRAGE may be novel biomarker for the prediction of coronary artery disease in non-diabetic subjects.
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KEYWORD
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Advanced glycation end products, Receptor for advanced glycation end products, coronary artery disease
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